Major depressive disorder or MDD is a complicated psychiatric disorder that affects nearly 20 percent of individuals at some point or the other. Medical science has also identified MDD as one of the primary causes of disability all over the world.
This condition is generally characterized by loss of interest, sudden mood changes, feelings of hopelessness and guilt, changes in sleep patterns and appetite.
Clinical Studies Relating Gut Bacteria to Depression
A preclinical study on depression documents the results of an investigation into the pre and post stress condition of the gut microbiome in mice. The examination results suggested that the significant change noted by investigating scientists was the near absence of Lactobacillus accompanied by a rise in the circulation of kynurenine metabolites. The latter is recognized as the driving force behind depression.
Further, L.reuteri supplementation for restoring Lactobacillus helped normalize the animal’s behaviour. According to researchers, the Lactobacillus-derives sympathetic oxygen species might sample with the kynurenine metabolism of the host. Therefore, probiotic bacteria can play a role in regulating metabolism while also enabling the animal to be more resilient to stress.
New Research: Proper Nutrition May Treat MDD
The latest research on the relationship between MDD and gut bacteria suggests that most people suffering from this psychiatric disorder tend to underestimate the impact of nutrition on MDD.
Those suffering from MDD are proven to show increased amounts of pro-inflammatory cytokines, altered gastrointestinal function, heightened oxidative stress and reduced omega 3 fatty acids and micronutrient levels in their body.
According to medical experts, if you have MDD, the bacterial growth in your small intestine (also known as SIBO or Small intestinal bacterial growth) is likely to cause limited absorption of nutrients in the body.
The GI (gastrointestinal) microflora is also altered significantly due to chronic stress conditions. This lowers the bifidobacterium and lactobacilli levels in the gut. In fact, approximately 30 percent of MDD patients are diagnosed with IBS or irritable bowel syndrome.
Extensive research done over years suggests that probiotics have the ability to reduce systemic inflammatory cytokines, enhance nutritional status, treat SIBO and minimize oxidative stress. Beneficial bacteria found in probiotics also have a positive impact on the B vitamin status, mineral absorption and the omega-3 status in the body. Probiotics can act as powerful antioxidants, especially in preventing lipid peroxidation and this help improves symptoms of MDD.
To conclude, healthy amounts of Lactobacillus bacteria in the gut are necessary for minimizing the symptoms associated with major depressive disorder.
Disclaimer: The vitamin health information published on this web page is solely intended for educational purposes. VitaminsOnly strongly recommends to consult health care professionals for any questions concerning your health.
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